Despite tremendous progress in basic science, there have been no new breakthroughs in the treatment of many CNS diseases.

    CNS quantitative systems pharmacology is based on the realization that human pathology is driven by a network imbalance rather than deficits at a single target or gene.

    Computer-based modeling of biophysically realistic neuronal network circuits calibrated with human imaging and clinical data is a translational tool to assess the outcome of therapeutic interventions in complex brain circuits.